Last Updated: 06/23/05

interdisciplinary Program In Drug Discovery

University of Southern California

Department of Chemistry - College of Letters, Arts & Sciences

Department of Pharmaceutical Sciences - School of Pharmacy


1st Annual iPIDD Retreat

Event Information

Location

Descansco Gardens

Flintridge/La Canada

Date

June 17, 2005

Time

8:00 am - 3:00 pm


Schedule for iPIDD Retreat, June 17, 2005

Schedule(Word Download)

8:00 – 8:45

Arrival, poster setup, breakfast

8:45 – 9:00

Introduction (Drs. Ian Haworth and Charles McKenna)                       

Session 1

Chairs: Angela Li (PSCI) & Sayantan Mitra (CHEM)

9:00 – 9:20

Laith Al-Mawsawi

"Discovery of a Novel Small Molecule HIV-1 Integrase Inhibitor Binding Site through Photoaffinity Labeling and Mass Spectrometry"

9:20 – 9:40

Stefani Thomas

      "A Shotgun Proteomic Approach to the Analysis of Altered Synaptic Signaling Pathways During the Course of Neurodegeneration"               

9:40 – 10:00 

Thomas Upton

"Synthesis and Characterization of Novel, b,g-methylene-substituted Analogs of dNTPs: For Probing the Effects on DNA Polymerase b Catalysis and Fidelity"

10:00 – 10:20

Christopher Sucato

"Kinetic Studies on the Mechanism of DNA Polymerase Beta Catalysis and Fidelity"

10:30 – 10:45

Coffee Break                

Session 2 

Chairs: Jeff Grell (PSCI) & Joy Bala (CHEM)

10:45 – 11:05

Alexandra Schiewe

"Computational Prediction of MHC-peptide-TCR Interactions"

 11:05 – 11:25

Caitlin Hubbard

"Protein Tyrosine Phosphatases: Developing an understanding of enzyme activity through substrate and inhibitor libraries"                   

11:25 – 11:45 

Gerald Nagatani

"The Direct Regulation of the Gastric H,K-ATPase by Phosphatidylinositol Phosphates"

12:00 – 1:00

Lunch, Brainstorming session

Session 3

Chairs: Thejani Rajapaksa (PSCI) & Matt Franzman (CHEM)                   

1:00 – 1:20 

James Hogan

"Synthesis and Applications of Bisphosphonate Drugs in Various Fields of Medicinal Chemistry"

 1:20 – 1:40 

Jennica Zaro

"Cytosolic Delivery of Bioactive Molecules via Membrane Transduction"

1:40 – 2:00  

Shamila Gunatilleke

     "Investigating the Antiarthritic Activity of Au(I)"              

Poster Session

Chairs: Alexandra Schiewe (PSCI) & Thomas Upton (CHEM)

  2:00 – 2:30

Two-minute oral presentations from each poster presenter

2:30 – 3:00  

Open discussion of posters

                   


List of posters:

Joy Lynn Bala (CHEM)

"Fluorescently Labeled Drug Analogs"

Ulrika Eriksson & Larryn Krause (CHEM)

"Synthesis and Biological Evaluation of Novel Cidofovir Prodrugs"

Matthew Franzman (CHEM)

"Mechanism of Medicinal Gold Antiarthritic Activity: Interaction of Au(I) with Transcription Factors and Disulfide Bonds"

Jeffrey Grell (PSCI)

"Non-Invasive Measurement of Pressure Using DCE-MRI"

 James Hogan (CHEM)

"Bisphosphonates in Medicinal Chemistry"

Mark Karver (CHEM)

"Characterization of the Binding of Au(I) to the Cathepsins: A Family of Lysosomal Cysteine Proteases"

Angela Li (PSCI)

"UV-Inducible RNA Interference"

Sayantan Mitra (CHEM)

'Synthesis and Analysis of a Fluorescent Probe for Studying Protein Tyrosine Phosphatases"

Thejani Rajapaksa (PSCI)

"Characterization of the Role of LIM and SH3 Protein-1 (LASP-1) in Endocytosis"

Brian Sutch (PSCI)

"Molecular Modeling of Zebularine: an Anti-Cancer Agent that Incorporates into DNA"

Zahrah Zawahir (PSCI)

"Inhibition of HIV-1 Integrase Activity by Synthetic Peptides Derived from the HIV-1 HXB2 Pol Region of the Viral Genome"

 

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